ABSTRACT
Background: There is paucity of information regarding the effects of cholecystectomy on serum lipid profile parameters and blood glucose levels in the patients of cholelithiasis. Therefore, this study was undertaken to compare some serum lipid parameters and blood glucose levels in patients of cholelithiasis and effect of cholecystectomy on the same.Methods: The study was conducted on 50 patients of cholelithiasis who were admitted in Surgery department, MLN Medical College over a period of one year and were planned for cholecystectomy. Complete lipid profile (which included total cholesterol, triglycerides, high density lipoproteins (HDL) cholesterol, low density lipoproteins (LDL), very low density lipoproteins (VLDL) and atherogenic index) and fasting blood glucose was evaluated pre-operatively and post-operatively on the 3rd, 7th and further after 1 month of cholecystectomy. Results: Out of 50 patients, maximum of 38% were in their 4th decade with females constituting 82% of total. There was significant elevation in fasting blood glucose and HDL cholesterol on 3rd, 7th and 30th day post-cholecystectomy as compared to pre-operative values (p value<0.0001). Triglyceride and VLDL cholesterol elevated on 3rd and 7th day but it significantly decreased one-month post-cholecystectomy as compared to pre-operative levels (p value<0.0001). However, LDL, total cholesterol and atherogenic index significantly decreased on 3rd ,7th and 30th day post-cholecystectomy.Conclusions: Cholelithiasis is an important cause associated with significant pathological changes in many lipid profile parameters, which will return towards normal after cholecystectomy. This normalization will be a time dependent phenomenon with long term beneficial effects.
ABSTRACT
Background: Hepatitis B is a global public health problem that causes chronic liver disease and death due to Cirrhosis of liver and Hepatocellular carcinoma. Prevalence of Hepatitis B is increasing in developing countries and there is a paucity of information among medical students regarding its transmission and vaccination. Scientific knowledge regarding the same is necessary for medical students for taking protective measures as Hepatitis B is highly communicable. Aim and objectives: To evaluate Knowledge, Attitude and Practice (KAP) among medical students towards HBV and correlate the level of awareness with the attitude they behold towards the disease, its transmission and prevention and to determine the vaccination status for Hepatitis B among medical students. Materials and methods: Cross sectional study where a total of 200 subjects including House surgeons were interviewed using a validated structured questionnaire Results: A total of 145 (72.5%) students were completely vaccinated with HBV vaccine. Among these, preclinical students were 76 (38 %) and clinical 69 (34.5%) in number. Around 96(48%) students felt they would not get Hepatitis B infection while 26(13%) thought Hepatitis B is selfcurable by the body. Students having good knowledge regarding HBV were 86 (43%), good attitude towards HBV were 125 (62.5%) and 145 (72.5%) followed good practice for HBV prevention. Abhinav Agarwal, J.E. Jeffin Shanu, Shankar K. Assessment of knowledge, attitude and practice about Hepatitis B among medical students in an urban area of Kanchipuram: A cross sectional study. IAIM, 2018; 5(4): 17-22. Page 18 Conclusion: This study showed fairly moderate outcomes with important gaps. Lack of vaccination of all the students makes them vulnerable to liver disease. It is mandatory that they be fully vaccinated prior to their entry into professional practice. In spite of having good knowledge, their practice for prevention was not satisfactory